(075) Exposing the Unsung Cycle: A Proposed Study to Examine the Connection Between Allopregnanolone and Adverse Mood Effects of Hormonal Contraception

Abstract Introduction Allopregnanolone is a GABAnergic neurosteroid. Reduced concentration of allopregnanolone in the cerebrospinal fluid (CSF) and serum are closely associated with several neuropsychiatric conditions, including Alzheimer’s disease, anxiety disorders, premenstrual dysphoric disorder, postpartum depression. progesterone metabolite predominantly synthesized women ovaries prior literature shows menstrual cycle directly affects CSF concentrations. We hypothesize that allopregnanolone’s biosynthesis similarly affected by exogenous hormonal contraceptives. In United States, 65% reproductive-aged use contraceptives their discontinuation commonly attributed to adverse changes mood; yet, little understood when it comes what how specific components affect mood manage such effects. Objective aim review current propose study understand connection between effects order improve women’s health. Methods conducted semi-systematic search, using PubMed Central other databases, compiling peer-reviewed material keywords AND contraceptives; combined oral contraceptive; progestin; suppression; levonorgestrel, ethinyl estradiol, medroxyprogesterone. All languages publication were included where reliable translations available. Studies excluded if they did not include and/or measurements allopregnanolone. Results Rodent studies demonstrated reduce both Human analyzing only concentrations showed same results, but no human identified. Only two have examined levels mood, done so context contraceptive use. Conclusions While sex hormones, namely progestins, rodents, impact on remains inconclusive under-researched humans. large multi-arm humans following administration assess metabolism This research will allow clinicians better tailor selection. Disclosure No